MicroRNA or not MicroRNA?

  • Authors:

  • David Langenberger;Sebastian Bartschat;Jana Hertel;Steve Hoffmann;Hakim Tafer;Peter F. Stadler

  • Affiliations:

  • Department of Computer Science and University of Leipzig, Leipzig, Germany and LIFE, University of Leipzig, Germany;Bioinformatics Group, Department of Computer Science;Bioinformatics Group, Department of Computer Science and University of Leipzig, Leipzig, Germany;LIFE, University of Leipzig, Germany and University of Leipzig, Leipzig, Germany;Bioinformatics Group, Department of Computer Science and University of Leipzig, Leipzig, Germany;Dept. of Comp. Sci. and Univ. of Leipzig, Germany and LIFE, Univ. of Leipzig, Germany and Max Planck Inst. for Math. in the Sci., Fraunhofer Inst. für Zelltherapie und Immunologie, Germany an ...

  • Venue:
  • BSB'11 Proceedings of the 6th Brazilian conference on Advances in bioinformatics and computational biology
  • Year:
  • 2011

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Abstract

The avalanche of next generation sequencing data has led to a rapid increase of annotated microRNAs in the last few years. Many of them are specific to individual species or rather narrow clades. A closer inspection of the current version of miRBase shows that dozens of entries conflict with other ncRNAs, in particular snoRNAs.With few exceptions, these cases show little similarities to canonical microRNAs, however, and thus they should be considered as mis-annotations.