A recursive sparse blind source separation method for nonnegative and correlated data in NMR spectroscopy

  • Authors:
  • Yuanchang Sun;Jack Xin

  • Affiliations:
  • Math Department, Univ of California Irvine, Irvine, CA;Math Department, Univ of California Irvine, Irvine, CA

  • Venue:
  • CAIP'11 Proceedings of the 14th international conference on Computer analysis of images and patterns - Volume Part II
  • Year:
  • 2011

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Abstract

Motivated by the nuclear magnetic resonance (NMR) spectroscopy of biofluids (urine and blood serum), we present a recursive blind source separation (rBSS) method for nonnegative and correlated data. A major approach to non-negative BSS relies on a strict nonoverlap condition (also known as the pixel purity assumption in hyperspectral imaging) of source signals which is not always guaranteed in the NMR spectra of chemical compounds. A new dominant interval condition is proposed. Each source signal dominates some of the other source signals in a hierarchical manner. The rBSS method then reduces the BSS problem into a series of sub-BSS problems by a combination of data clustering, linear programming, and successive elimination of variables. In each sub-BSS problem, an l1 minimization problem is formulated for recovering the source signals in a sparse transformed domain. The method is substantiated by NMR data.