Non-local shape descriptor: a new similarity metric for deformable multi-modal registration

Authors:
Mattias P. Heinrich;Mark Jenkinson;Manav Bhushan;Tahreema Matin;Fergus V. Gleeson;J. Michael Brady;Julia A. Schnabel
Affiliations:
Institute of Biomedical Engineering, University of Oxford, UK and Oxford University Centre for Functional MRI of the Brain, UK;Oxford University Centre for Functional MRI of the Brain, UK;Institute of Biomedical Engineering, University of Oxford, UK and Oxford University Centre for Functional MRI of the Brain, UK;Department of Radiology Churchill Hospital, Oxford, UK;Department of Radiology Churchill Hospital, Oxford, UK;Department of Radiation Oncology and Biology, University of Oxford, UK;Institute of Biomedical Engineering, University of Oxford, UK
Venue:
MICCAI'11 Proceedings of the 14th international conference on Medical image computing and computer-assisted intervention - Volume Part II
Year:
2011

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Abstract

Deformable registration of images obtained from different modalities remains a challenging task in medical image analysis. This paper addresses this problem and proposes a new similarity metric for multi-modal registration, the non-local shape descriptor. It aims to extract the shape of anatomical features in a non-local region. By utilizing the dense evaluation of shape descriptors, this new measure bridges the gap between intensity-based and geometric feature-based similarity criteria. Our new metric allows for accurate and reliable registration of clinical multi-modal datasets and is robust against the most considerable differences between modalities, such as non-functional intensity relations, different amounts of noise and non-uniform bias fields. The measure has been implemented in a non-rigid diffusion-regularized registration framework. It has been applied to synthetic test images and challenging clinical MRI and CT chest scans. Experimental results demonstrate its advantages over the most commonly used similarity metric - mutual information, and show improved alignment of anatomical landmarks.