Learning from only positive and unlabeled data to detect lesions in vascular CT images

  • Authors:
  • Maria A. Zuluaga;Don Hush;Edgar J. F. Delgado Leyton;Marcela Hernández Hoyos;Maciej Orkisz

  • Affiliations:
  • CREATIS, Université de Lyon, Université Lyon 1, INSA-Lyon, CNRS UMR5220, INSERM U1044, Villeurbanne, France and Grupo Imagine, Grupo de Ingeniería Biomédica, Universidad de los ...;Los Alamos National Laboratory, Los Alamos, NM;CREATIS, Université de Lyon, Université Lyon 1, INSA-Lyon, CNRS UMR5220, INSERM U1044, Villeurbanne, France and Grupo Imagine, Grupo de Ingeniería Biomédica, Universidad de los ...;Grupo Imagine, Grupo de Ingeniería Biomédica, Universidad de los Andes, Bogotá, Colombia;CREATIS, Université de Lyon, Université Lyon 1, INSA-Lyon, CNRS UMR5220, INSERM U1044, Villeurbanne, France

  • Venue:
  • MICCAI'11 Proceedings of the 14th international conference on Medical image computing and computer-assisted intervention - Volume Part III
  • Year:
  • 2011

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Abstract

Detecting vascular lesions is an important task in the diagnosis and follow-up of the coronary heart disease. While most existing solutions tackle calcified and non-calcified plaques separately, we present a new algorithm capable of detecting both types of lesions in CT images. It builds up on a semi-supervised classification framework, in which the training set is made of both unlabeled data and a small amount of data labeled as normal. Our method takes advantage of the arrival of newly acquired data to re-train the classifier and improve its performance. We present results on synthetic data and on datasets from 15 patients. With a small amount of labeled training data our method achieved a 89.8% true positive rate, which is comparable to state-of-the-art supervised methods, and the performance can improve after additional iterations.