Myocardial segmentation of late gadolinium enhanced MR images by propagation of contours from cine MR images

Authors:
Dong Wei;Ying Sun;Ping Chai;Adrian Low;Sim Heng Ong
Affiliations:
Department of Electrical and Computer Engineering, National University of Singapore, Singapore;Department of Electrical and Computer Engineering, National University of Singapore, Singapore;Cardiac Department, National University Heart Centre, Singapore;Cardiac Department, National University Heart Centre, Singapore;Department of Electrical and Computer Engineering, National University of Singapore, Singapore
Venue:
MICCAI'11 Proceedings of the 14th international conference on Medical image computing and computer-assisted intervention - Volume Part III
Year:
2011

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Abstract

Automatic segmentation of myocardium in Late Gadolinium Enhanced (LGE) Cardiac MR (CMR) images is often difficult due to the intensity heterogeneity resulting from accumulation of contrast agent in infarcted areas. In this paper, we propose an automatic segmentation framework that fully utilizes shared information between corresponding cine and LGE images of a same patient. Given myocardial contours in cine CMR images, the proposed framework achieves accurate segmentation of LGE CMR images in a coarse-to-fine manner. Affine registration is first performed between the corresponding cine and LGE image pair, followed by nonrigid registration, and finally local deformation of myocardial contours driven by forces derived from local features of the LGE image. Experimental results on real patient data with expert outlined ground truth show that the proposed framework can generate accurate and reliable results for myocardial segmentation of LGE CMR images.