Multiple mean models of statistical shape and probability priors for automatic prostate segmentation

  • Authors:

  • Soumya Ghose;Arnau Oliver;Robert Martí;Xavier Lladó;Jordi Freixenet;Jhimli Mitra;Joan C. Vilanova;Josep Comet;Fabrice Meriaudeau

  • Affiliations:

  • Computer Vision and Robotics Group, University of Girona, Edifici P-IV, Girona, Spain and Laboratoire Le2I - UMR CNRS 5158, Université de Bourgogne, Le Creusot, France;Computer Vision and Robotics Group, University of Girona, Edifici P-IV, Girona, Spain;Computer Vision and Robotics Group, University of Girona, Edifici P-IV, Girona, Spain;Computer Vision and Robotics Group, University of Girona, Edifici P-IV, Girona, Spain;Computer Vision and Robotics Group, University of Girona, Edifici P-IV, Girona, Spain;Computer Vision and Robotics Group, University of Girona, Edifici P-IV, Girona, Spain and Laboratoire Le2I - UMR CNRS 5158, Université de Bourgogne, Le Creusot, France;Girona Magnetic Resonance Imaging Center, Girona, Spain;University Hospital Dr. Josep Trueta, Girona, Spain;Laboratoire Le2I - UMR CNRS 5158, Université de Bourgogne, Le Creusot, France

  • Venue:
  • MICCAI'11 Proceedings of the 2011 international conference on Prostate cancer imaging: image analysis and image-guided interventions
  • Year:
  • 2011

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Abstract

Low contrast of the prostate gland, heterogeneous intensity distribution inside the prostate region, imaging artifacts like shadow regions, speckle and significant variations in prostate shape, size and inter dataset contrast in Trans Rectal Ultrasound (TRUS) images challenge computer aided automatic or semi-automatic segmentation of the prostate. In this paper, we propose a probabilistic framework for automatic initialization and propagation of multiple mean parametric models derived from principal component analysis of shape and posterior probability information of the prostate region to segment the prostate. Unlike traditional statistical models of shape and intensity priors we use posterior probability of the prostate region to build our texture model of the prostate and use the information in initialization and propagation of the mean model. Furthermore, multiple mean models are used compared to a single mean model to improve segmentation accuracies. The proposed method achieves mean Dice Similarity Coefficient (DSC) value of 0.97±0.01, and mean Mean Absolute Distance (MAD) value of 0.49±0.20 mm when validated with 23 datasets with considerable shape, size, and intensity variations, in a leave-one-patient-out validation framework. The model achieves statistically significant t-test p-value