Heritability of white matter fiber tract shapes: a HARDI study of 198 twins

Authors:
Yan Jin;Yonggang Shi;Shantanu H. Joshi;Neda Jahanshad;Liang Zhan;Greig I. De Zubicaray;Katie L. McMahon;Nicholas G. Martin;Margaret J. Wright;Arthur W. Toga;Paul M. Thompson
Affiliations:
Laboratory of Neuro Imaging, Department of Neurology, School of Medicine, University of California, Los Angeles, CA;Laboratory of Neuro Imaging, Department of Neurology, School of Medicine, University of California, Los Angeles, CA;Laboratory of Neuro Imaging, Department of Neurology, School of Medicine, University of California, Los Angeles, CA;Laboratory of Neuro Imaging, Department of Neurology, School of Medicine, University of California, Los Angeles, CA;Laboratory of Neuro Imaging, Department of Neurology, School of Medicine, University of California, Los Angeles, CA;fMRI Laboratory, University of Queensland, Brisbane St. Lucia, QLD, Australia;fMRI Laboratory, University of Queensland, Brisbane St. Lucia, QLD, Australia;Queensland Institute of Medical Research, Herston, QLD, Australia;Queensland Institute of Medical Research, Herston, QLD, Australia;Laboratory of Neuro Imaging, Department of Neurology, School of Medicine, University of California, Los Angeles, CA;Laboratory of Neuro Imaging, Department of Neurology, School of Medicine, University of California, Los Angeles, CA
Venue:
MBIA'11 Proceedings of the First international conference on Multimodal brain image analysis
Year:
2011

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Abstract

Genetic analysis of diffusion tensor images (DTI) shows great promise in revealing specific genetic variants that affect brain integrity and connectivity. Most genetic studies of DTI analyze voxel-based diffusivity indices in the image space (such as 3D maps of fractional anisotropy) and overlook tract geometry. Here we propose an automated workflow to cluster fibers using a white matter probabilistic atlas and perform genetic analysis on the shape characteristics of fiber tracts. We apply our approach to large study of 4-Tesla high angular resolution diffusion imaging (HARDI) data from 198 healthy, young adult twins (age: 20-30). Illustrative results show heritability for the shapes of several major tracts, as color-coded maps.