The use of a formal sensitivity analysis on epidemic models with immune protection from maternally acquired antibodies

Authors:
J. D. Chapman;M. J. Chappell;N. D. Evans
Affiliations:
School of Engineering, University of Warwick, Coventry, CV4 7AL, United Kingdom;School of Engineering, University of Warwick, Coventry, CV4 7AL, United Kingdom;School of Engineering, University of Warwick, Coventry, CV4 7AL, United Kingdom
Venue:
Computer Methods and Programs in Biomedicine
Year:
2011

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Abstract

Abstract: This paper considers the outcome of a formal sensitivity analysis on a series of epidemic model structures developed to study the population level effects of maternal antibodies. The analysis is used to compare the potential influence of maternally acquired immunity on various age and time domain observations of infection and serology, with and without seasonality. The results of the analysis indicate that time series observations are largely insensitive to variations in the average duration of this protection, and that age related empirical data are likely to be most appropriate for estimating these characteristics.