An introduction to variable and feature selection
The Journal of Machine Learning Research
A review of feature selection techniques in bioinformatics
Bioinformatics
Bioinformatics
Pattern Recognition and Neural Networks
Pattern Recognition and Neural Networks
Molecular surface mesh generation by filtering electron density map
Journal of Biomedical Imaging - Special issue on mathematical methods for images and surfaces
Fast Surface-Based Travel Depth Estimation Algorithm for Macromolecule Surface Shape Description
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
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A B-cell epitope is a part of an antigen that is recognized by a specific antibody or B-cell receptor. Detecting the immunogenic region of the antigen is useful in numerous immunodetection and immunotherapeutics applications. The aim of this paper is to find relevant properties to discriminate the location of potential epitopes from the rest of the protein surface. The most relevant properties, identified using two evaluation approaches, are the geometric properties, followed by the conservation score and some chemical properties, such as the proportion of glycine. The selected properties are used in a patch-based epitope localization method including a Single-Layer Perceptron for regression. The output of this Single-Layer Perceptron is used to construct a probability map on the antigen surface. The predictive performances of the method are assessed by computing the AUC using cross validation on two benchmark data sets and by computing the AUC and the precision for a third independent test set.