Modeling the interaction of the immune system with HIV
Mathematical and statistical approaches to AIDS epidemiology
Persistence under relaxed point-dissipativity (with application to an endemic model)
SIAM Journal on Mathematical Analysis
Mathematical Analysis of HIV-1 Dynamics in Vivo
SIAM Review
M-matrices and local stability in epidemic models
Mathematical and Computer Modelling: An International Journal
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In this paper we derive a model describing the dynamics of HIV-1 infection in tissue culture where the infection spreads directly from infected cells to healthy cells trough cell-to-cell contact. We assume that the infection rate between healthy and infected cells is a saturating function of cell concentration. Our analysis shows that if the basic reproduction number does not exceed unity then infected cells are cleared and the disease dies out. Otherwise, the infection is persistent with the existence of an infected equilibrium. Numerical simulations indicate that, depending on the fraction of cells surviving the incubation period, the solutions approach either an infected steady state or a periodic orbit.