Renal cancer cell classification using generative embeddings and information theoretic kernels

  • Authors:
  • Manuele Bicego;Aydin Ulaş;Peter Schüffler;Umberto Castellani;Vittorio Murino;André Martins;Pedro Aguiar;Mario Figueiredo

  • Affiliations:
  • University of Verona, Department of Computer Science, Verona, Italy;University of Verona, Department of Computer Science, Verona, Italy;ETH Zürich, Department of Computer Science, Zürich, Switzerland;University of Verona, Department of Computer Science, Verona, Italy and Istituto Italiano di Tecnologia, Genova, Italy;University of Verona, Department of Computer Science, Verona, Italy;Instituto de Telecomunicações, Lisboa, Portugal and Instituto Superior Técnico, Technical University of Lisbon, Portugal;Instituto de Sistemas e Robótica, Lisboa, Portugal and Instituto Superior Técnico, Technical University of Lisbon, Portugal;Instituto de Telecomunicações, Lisboa, Portugal and Instituto Superior Técnico, Technical University of Lisbon, Portugal

  • Venue:
  • PRIB'11 Proceedings of the 6th IAPR international conference on Pattern recognition in bioinformatics
  • Year:
  • 2011

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Abstract

In this paper, we propose a hybrid generative/discriminative classification scheme and apply it to the detection of renal cell carcinoma (RCC) on tissue microarray (TMA) images. In particular we use probabilistic latent semantic analysis (pLSA) as a generative model to perform generative embedding onto the free energy score space (FESS). Subsequently, we use information theoretic kernels on these embeddings to build a kernel based classifier on the FESS. We compare our results with support vector machines based on standard linear kernels and RBF kernels; and with the nearest neighbor (NN) classifier based on the Mahalanobis distance using a diagonal covariance matrix. We conclude that the proposed hybrid approach achieves higher accuracy, revealing itself as a promising approach for this class of problems.