Estimating the class posterior probabilities in protein secondary structure prediction

  • Authors:
  • Yann Guermeur;Fabienne Thomarat

  • Affiliations:
  • LORIA, Vandœuvre-lès-Nancy Cedex, France;LORIA, Vandœuvre-lès-Nancy Cedex, France

  • Venue:
  • PRIB'11 Proceedings of the 6th IAPR international conference on Pattern recognition in bioinformatics
  • Year:
  • 2011

Quantified Score

Hi-index 0.00

Visualization

Abstract

Support vector machines, let them be bi-class or multi-class, have proved efficient for protein secondary structure prediction. They can be used either as sequence-to-structure classifier, structure-to-structure classifier, or both. Compared to the classifier most commonly found in the main prediction methods, the multi-layer perceptron, they exhibit one single drawback: their outputs are not class posterior probability estimates. This paper addresses the problem of post-processing the outputs of multi-class support vector machines used as sequence-to-structure classifiers with a structure-to-structure classifier estimating the class posterior probabilities. The aim of this comparative study is to obtain improved performance with respect to both criteria: prediction accuracy and quality of the estimates.