Modeling Cell Movement and Chemotaxis Using Pseudopod-Based Feedback

Authors:
M. P. Neilson;J. A. Mackenzie;S. D. Webb;R. H. Insall
Affiliations:
matthew.nielson@strath.ac.uk and j.a.mackenzie@strath.ac.uk and steven.webb@strath.ac.uk;-;-;R.insall@beatson.gla.ac.uk
Venue:
SIAM Journal on Scientific Computing
Year:
2011

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Abstract

A computational framework is presented for the simulation of eukaryotic cell migration and chemotaxis. An empirical pattern formation model, based on a system of nonlinear reaction-diffusion equations, is approximated on an evolving cell boundary using an arbitrary Lagrangian Eulerian surface finite element method (ALE-SFEM). The solution state is used to drive a mechanical model of the protrusive and retractive forces exerted on the cell boundary. Movement of the cell is achieved using a level set method. Results are presented for cell migration with and without chemotaxis. The simulated behavior is compared with experimental results of migrating Dictyostelium discoideum cells.