Current Topics in Computational Molecular Biology
Current Topics in Computational Molecular Biology
CSB '02 Proceedings of the IEEE Computer Society Conference on Bioinformatics
Efficient Constrained Multiple Sequence Alignment with Performance Guarantee
CSB '03 Proceedings of the IEEE Computer Society Conference on Bioinformatics
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For finding accurate and biologically meaningful multiple sequence alignment, it is required to consider a loosely constrained version of multiple sequence alignment. This paper is the first to define a loosely constrained multiple sequence alignment (LCMSA). And it also designs a complete algorithm for the loosely constrained pair-wise sequence alignment problem with the time complexity of O((α+1)n2(α+1)) and an approximation algorithm for LCMSA running in time O(k2(α+1)n2(α+1)), k and n is the number and the maximum length of input sequences, and α is the length of constrained sequence. In fact, α is small compared to n and it is reasonable to regard it as a constant. So, the former two algorithms run in polynomial time. Finally, a LCMSA software system is built up.