Tree-Dependent components of gene expression data for clustering

  • Authors:
  • Jong Kyoung Kim;Seungjin Choi

  • Affiliations:
  • Department of Computer Science, Pohang University of Science and Technology, Pohang, Korea;Department of Computer Science, Pohang University of Science and Technology, Pohang, Korea

  • Venue:
  • ICANN'06 Proceedings of the 16th international conference on Artificial Neural Networks - Volume Part II
  • Year:
  • 2006

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Abstract

Tree-dependent component analysis (TCA) is a generalization of independent component analysis (ICA), the goal of which is to model the multivariate data by a linear transformation of latent variables, while latent variables fit by a tree-structured graphical model. In contrast to ICA, TCA allows dependent structure of latent variables and also consider non-spanning trees (forests). In this paper, we present a TCA-based method of clustering gene expression data. Empirical study with yeast cell cycle-related data, yeast metabolic shift data, and yeast sporulation data, shows that TCA is more suitable for gene clustering, compared to principal component analysis (PCA) as well as ICA.