Model deconstruction of an immunoprevention vaccine

Authors:
F. Pappalardo;P. -L. Lollini;S. Motta;E. Mastriani
Affiliations:
Faculty of Pharmacy, University of Catania;Sezione di Cancerologia, Dipartimento di Patologia Sperimentale, and Centro Interdipartimentale di Ricerche sul Cancro ”Giorgio Prodi”, University of Bologna;Department of Mathematics and Computer Science, University of Catania;Department of Mathematics and Computer Science, University of Catania
Venue:
ICNC'06 Proceedings of the Second international conference on Advances in Natural Computation - Volume Part II
Year:
2006

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Abstract

We present a further step in developing an in silico model that simulates the immune system responses to tumor cells in vaccinated mice. Our study is based on our previous model that simulates the cancer – immune System competition activated by a tumor vaccine. In what follows, we show first results on effects of deconstructing the components of Triplex vaccine that are in very good agreement with in vivo results.