Scale-Space and Edge Detection Using Anisotropic Diffusion
IEEE Transactions on Pattern Analysis and Machine Intelligence
The Correlation Ratio as a New Similarity Measure for Multimodal Image Registration
MICCAI '98 Proceedings of the First International Conference on Medical Image Computing and Computer-Assisted Intervention
Cross Validation of Three Inter-Patients Matching Methods
VBC '96 Proceedings of the 4th International Conference on Visualization in Biomedical Computing
Measuring Lesion Growth from 3D Medical Images
NAM '97 Proceedings of the 1997 IEEE Workshop on Motion of Non-Rigid and Articulated Objects (NAM '97)
Tracer kinetic model-driven registration for dynamic contrast enhanced MRI time series
MICCAI'05 Proceedings of the 8th international conference on Medical Image Computing and Computer-Assisted Intervention - Volume Part I
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Motion during the acquisition of dynamic contrast enhanced MRI can cause model-fitting errors requiring co-registration. Clinical implementations use a pharmacokinetic model to determine lesion parameters from the contrast passage. The input to the model is the time-intensity plot from a region of interest (ROI) covering the lesion extent. Motion correction meanwhile involves interpolation and smoothing operations thereby affecting the time-intensity plots. This paper explores the trade-offs in applying an elastic matching procedure on the lesion detection and proposes enhancements. The method of choice is the 3D realization of the Demon’s elastic matching procedure. We validate our enhancements using synthesized deformation of stationary datasets that also serve as ground-truth. The framework is tested on 42 human eye datasets. Hence, we show that motion correction is beneficial in improving the model-fit and yet needs enhancements to correct for the intensity reductions during parameter estimation.