EAST: energy alignment search tool

Authors:
Dariusz Mrozek;Bożena Małysiak;Stanisław Kozielski
Affiliations:
Department of Computer Science, Silesian University of Technology, Gliwice, Poland;Department of Computer Science, Silesian University of Technology, Gliwice, Poland;Department of Computer Science, Silesian University of Technology, Gliwice, Poland
Venue:
FSKD'06 Proceedings of the Third international conference on Fuzzy Systems and Knowledge Discovery
Year:
2006

Citing 2
Cited 2

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Abstract

The inspection of structural changes (in selected proteins' regions) that take place in particular reactions of signal pathways is very important for their analysis. Conformational modifications as an effect of biochemical reactions or environmental influences cause changes in the conformational energy distributions. Observations of the energy characteristics allow to detect structural changes of selected proteins. In the paper, we present the EAST – method of similarity searching based on energy profiles. This method can be employed to find similar proteins during the analysis of substrates of signal paths' reactions and to detect regions of protein structure modifications.