Scoring method for tumor prediction from microarray data using an evolutionary fuzzy classifier

Authors:
Shinn-Ying Ho;Chih-Hung Hsieh;Kuan-Wei Chen;Hui-Ling Huang;Hung-Ming Chen;Shinn-Jang Ho
Affiliations:
Institute of Bioinformatics, National Chiao Tung University, Hsinchu, Taiwan;Institute of Bioinformatics, National Chiao Tung University, Hsinchu, Taiwan;Institute of Bioinformatics, National Chiao Tung University, Hsinchu, Taiwan;Department of Information Management, Jin Wen Institute of Technology, Hsin-Tien, Taipei, Taiwan;Institute of Information Engineering and Computer Science, Feng Chia University, Taichung, Taiwan;Department of Automation Engineering, National Formosa University, Huwei, Yunlin, Taiwan
Venue:
PAKDD'06 Proceedings of the 10th Pacific-Asia conference on Advances in Knowledge Discovery and Data Mining
Year:
2006

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Abstract

In this paper, we propose a novel scoring method for tumor prediction using an evolutionary fuzzy classifier which can provide accurate and interpretable information. The merits of the proposed method are threefold. 1) The score ranged in [0, 100] can further illustrate the degree of tumor status in contrast to the conventional tumor classifier. 2) The derived score system can be used as a tumor classifier using a system-suggested or human-specified threshold value. 3) The derived classifier with a compact fuzzy rule base can generate an interpretable and accurate prediction result. The effectiveness of the proposed method is evaluated and compared using two well-known datasets from microarray data and an existing tumor classifier. It is shown by computer simulation that the proposed scoring method is effective using ROC curves of classification.