Efficient search for association rules
Proceedings of the sixth ACM SIGKDD international conference on Knowledge discovery and data mining
Mining unexpected rules by pushing user dynamics
Proceedings of the ninth ACM SIGKDD international conference on Knowledge discovery and data mining
Mining risk patterns in medical data
Proceedings of the eleventh ACM SIGKDD international conference on Knowledge discovery in data mining
Analysis of breast feeding data using data mining methods
AusDM '06 Proceedings of the fifth Australasian conference on Data mining and analystics - Volume 61
Privacy-preserving sequential pattern release
PAKDD'07 Proceedings of the 11th Pacific-Asia conference on Advances in knowledge discovery and data mining
Practical issues on privacy-preserving health data mining
PAKDD'07 Proceedings of the 2007 international conference on Emerging technologies in knowledge discovery and data mining
Mining consequence events in temporal health data
Intelligent Data Analysis - Knowledge Discovery in Bioinformatics
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Adverse reactions to drugs are a leading cause of hospitalisation and death worldwide. Most post-marketing Adverse Drug Reaction (ADR) detection techniques analyse spontaneous ADR reports which underestimate ADRs significantly. This paper aims to signal ADRs from administrative health databases in which data are collected routinely and are readily available. We introduce a new knowledge representation, Unexpected Temporal Association Rules (UTARs), to describe patterns characteristic of ADRs. Due to their unexpectedness and infrequency, existing techniques cannot perform effectively. To handle this unexpectedness we introduce a new interestingness measure, unexpected-leverage, and give a user-based exclusion technique for its calculation. Combining it with an event-oriented data preparation technique to handle infrequency, we develop a new algorithm, MUTARA, for mining simple UTARs. MUTARA effectively short-lists some known ADRs such as the disease esophagitis unexpectedly associated with the drug alendronate. Similarly, MUTARA signals atorvastatin followed by nizatidine or dicloxacillin which may be prescribed to treat its side effects stomach ulcer or urinary tract infection, respectively. Compared with association mining techniques, MUTARA signals potential ADRs more effectively.