Mining biologically significant co-regulation patterns from microarray data

  • Authors:
  • Yuhai Zhao;Ying Yin;Guoren Wang

  • Affiliations:
  • Institute of Computer System, Northeastern University, Shengyang, China;Institute of Computer System, Northeastern University, Shengyang, China;Institute of Computer System, Northeastern University, Shengyang, China

  • Venue:
  • RSKT'06 Proceedings of the First international conference on Rough Sets and Knowledge Technology
  • Year:
  • 2006

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Abstract

In this paper, we propose a novel model, namely g-Cluster, to mine biologically significant co-regulated gene clusters. The proposed model can (1) discover extra co-expressed genes that cannot be found by current pattern/tendency-based methods, and (2) discover inverted relationship overlooked by pattern/tendency-based methods. We also design two tree-based algorithms to mine all qualified g-Clusters. The experimental results show: (1) our approaches are effective and efficient, and (2) our approaches can find an amount of co-regulated gene clusters missed by previous models, which are potentially of high biological significance