Watersheds in Digital Spaces: An Efficient Algorithm Based on Immersion Simulations
IEEE Transactions on Pattern Analysis and Machine Intelligence
Machine Learning
Deformation Analysis for Shape Based Classification
IPMI '01 Proceedings of the 17th International Conference on Information Processing in Medical Imaging
Shape versus Size: Improved Understanding of the Morphology of Brain Structures
MICCAI '01 Proceedings of the 4th International Conference on Medical Image Computing and Computer-Assisted Intervention
An introduction to variable and feature selection
The Journal of Machine Learning Research
Variable selection using svm based criteria
The Journal of Machine Learning Research
On the Use of Morphometry Based Features for Alzheimer's Disease Detection on MRI
IWANN '09 Proceedings of the 10th International Work-Conference on Artificial Neural Networks: Part I: Bio-Inspired Systems: Computational and Ambient Intelligence
Results of an Adaboost Approach on Alzheimer's Disease Detection on MRI
IWINAC '09 Proceedings of the 3rd International Work-Conference on The Interplay Between Natural and Artificial Computation: Part II: Bioinspired Applications in Artificial and Natural Computation
A Unified Framework for MR Based Disease Classification
IPMI '09 Proceedings of the 21st International Conference on Information Processing in Medical Imaging
Semisupervised probabilistic clustering of brain MR images including prior clinical information
MCV'10 Proceedings of the 2010 international MICCAI conference on Medical computer vision: recognition techniques and applications in medical imaging
Computers in Biology and Medicine
International Journal of Software Science and Computational Intelligence
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This paper presents a method for classification of medical images, using machine learning and deformation-based morphometry. A morphological representation of the anatomy of interest is first obtained using high-dimensional template warping, from which regions that display strong correlations between morphological measurements and the classification (clinical) variable are extracted using a watershed segmentation, taking into account the regional smoothness of the correlation map which is estimated by a cross-validation strategy in order to achieve robustness to outliers. A Support Vector Machine-Recursive Feature Elimination (SVM-RFE) technique is then used to rank computed features from the extracted regions, according to their effect on the leave-one-out error bound. Finally, SVM classification is applied using the best set of features, and it is tested using leave-one-out. The results from a group of 61 brain images of female normal controls and schizophrenia patients demonstrate not only high classification accuracy (91.8%) and steep ROC curves, but also exceptional stability with respect to the number of selected features and the SVM kernel size.