Simultaneous registration and segmentation of anatomical structures from brain MRI

Authors:
Fei Wang;Baba C. Vemuri
Affiliations:
Department of Computer & Information Sciences & Engr., University of Florida, Gainesville, FL;Department of Computer & Information Sciences & Engr., University of Florida, Gainesville, FL
Venue:
MICCAI'05 Proceedings of the 8th international conference on Medical Image Computing and Computer-Assisted Intervention - Volume Part I
Year:
2005

Citing 7
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Abstract

In this paper, we present a novel variational formulation of the registration assisted image segmentation problem which leads to solving a coupled set of nonlinear PDEs that are solved using efficient numerical schemes. Our work is a departure from earlier methods in that we have a unified variational principle wherein non-rigid registration and segmentation are simultaneously achieved; unlike previous methods of solution for this problem, our algorithm can accommodate for image pairs having very distinct intensity distributions. We present examples of performance of our algorithm on synthetic and real data sets along with quantitative accuracy estimates of the registration.