A multi-population χ2 test approach to informative gene selection

Authors:
Jun Luo;Jinwen Ma
Affiliations:
Department of Information Science, School of Mathematical Sciences and LMAM, Peking University, Beijing, China;Department of Information Science, School of Mathematical Sciences and LMAM, Peking University, Beijing, China
Venue:
IDEAL'05 Proceedings of the 6th international conference on Intelligent Data Engineering and Automated Learning
Year:
2005

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Abstract

This paper proposes a multi-population χ2 test method for informative gene selection of a tumor from microarray data based on the statistical multi-population χ2 test with the sample data being grouped evenly. To test the effectiveness of the multi-population χ2 test method, we use the support vector machine (SVM) to construct a tumor diagnosis system (i.e., a binary classifier) based on the identified informative genes on the colon and leukemia data. It is shown by the experiments that the constructed diagnosis system with the multi-population χ2 test method can 100% correctness rate of diagnosis on colon dataset and 97.1% correctness rate of diagnosis on leukemia dataset, respectively.