Bayesian population modeling of effective connectivity.

  • Authors:
  • Eric R. Cosman;William M. Wells-III

  • Affiliations:
  • Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA;Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA

  • Venue:
  • IPMI'05 Proceedings of the 19th international conference on Information Processing in Medical Imaging
  • Year:
  • 2005

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Abstract

A hierarchical model based on the Multivariate Autoreges- sive (MAR) process is proposed to jointly model neurological time-series collected from multiple subjects, and to characterize the distribution of MAR coefficients across the population from which those subjects were drawn. Thus, inference about effective connectivity between brain re- gions may be generalized beyond those subjects studied. The posterior on population- and subject-level connectivity parameters are estimated in a Variational Bayesian (VB) framework, and structural model param- eters are chosen by the corresponding evidence criteria. The significance of resulting connectivity statistics are evaluated by permutation-based approximations to the null distribution. The method is demonstrated on simulated data and on actual multi-subject neurological time-series.