Combination of network construction and cluster analysis and its application to traditional chinese medicine

  • Authors:
  • Mingfeng Wang;Zhi Geng;Miqu Wang;Feng Chen;Weijun Ding;Ming Liu

  • Affiliations:
  • School of Mathematical Sciences, Peking University, Beijing, China;School of Mathematical Sciences, Peking University, Beijing, China;Chengdu University of Traditional Chinese Medicine, Chengdu, China;School of Mathematical Sciences, Peking University, Beijing, China;Chengdu University of Traditional Chinese Medicine, Chengdu, China;Chengdu University of Traditional Chinese Medicine, Chengdu, China

  • Venue:
  • ISNN'06 Proceedings of the Third international conference on Advances in Neural Networks - Volume Part III
  • Year:
  • 2006

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Abstract

Bayesian networks and cluster analysis are widely applied to network construction, data mining and causal discovery in bioinformation and medical researches. A Bayesian network is used to describe associations among a large number of variables, such as a gene network and a network describing relationships among symptoms. Cluster analysis is used to cluster associated variables, For example, genes with similar expressions or associated symptoms are grouped into a cluster. In this paper, we combine these approaches of network construction and cluster analysis together. On the one hand, we use Bayesian networks to explain relationships among variables in each cluster; on the other hand we use hierarchical cluster approach to assist network construction, and we propose a structure learning approach. In the stepwise approach, a subnetwork over a larger cluster is constructed by combining several subnetworks over small clusters whenever these small clusters are grouped together. The proposed approach is applied to a traditional Chinese medical study on a kidney disease.