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This publication presents the use of semantic analysis in IT processes of data interpretation and understanding. These processes form a part of a field called cognitive informatics, which encompasses subjects related to the semantic analysis and interpretation of data leading to understanding the analysed data sets. Examples of applications of this type of analysis methods will be shown using the case of an IT system for the cognitive analysis of image data presenting X-ray images lesions. The presented UBIAS (Understanding Based Image Analysis Systems) designed for the cognitive analysis of image data are supplemented with processes of biometric analysis, identification and verification of persons. This type of solution can be introduced due to defining formalisms of linguistic data description proposed as part of E-UBIAS systems (Extended Understanding Based Image Analysis Systems). These systems are used for the personal and authentication analysis of an individual and form one of the main subjects of this publication. Semantic analysis dedicated to cognitive semantic interpretation solutions will be discussed using two different applications as examples. The first is about understanding medical image data showing lesions of foot bones. The second are the results of work on analysing palm bone lesions, which laid foundations for a new class of E-UBIAS systems for biometric verification and identification of persons.