Molecular gene expression signature patterns for gastric cancer diagnosis
Computational Biology and Chemistry
Algorithm Note: PK-means: A new algorithm for gene clustering
Computational Biology and Chemistry
Efficiency issues of evolutionary k-means
Applied Soft Computing
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In this paper, a novel gene expression clustering method known as eXploratory K-Means (XK-Means) is proposed. The method is based on the integration of the K-Means framework, and an exploratory mechanism to prevent premature convergence of the clustering process. Experimental results reveal that the performance of XK-Means in grouping gene expressions, measured in terms of speed, error and stability, is superior to existing methods that are based on evolutionary algorithm. In addition, the complexity of the proposed method is lower and the method can be easily implemented in practice.