Usability inspection methods
Readings in information visualization: using vision to think
Readings in information visualization: using vision to think
Tree-Maps: a space-filling approach to the visualization of hierarchical information structures
VIS '91 Proceedings of the 2nd conference on Visualization '91
Toward a Deeper Understanding of the Role of Interaction in Information Visualization
IEEE Transactions on Visualization and Computer Graphics
Journal of Biomedical Informatics
Journal of Biomedical Informatics
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Translational bioinformatics increasingly involves the discovery of associations between molecular and phenotype information, with the goal of transforming those discoveries into novel methods for diagnosis and treatment. To enable such complex analysis, researchers need approaches that provide the simultaneous representation and interactive analysis of patients, and their molecular and phenotype information. Because few existing visual analytical systems provide appropriate capabilities, we developed a prototypical visual analytical system called iCircos, which enables the simultaneous and interactive exploration of molecular and phenotype information. We discuss our overall method for developing the prototype by integrating user needs and design heuristics from visual analytics, with agile programming in HTML5 and SVG. A demonstration of the prototype to explore molecular and phenotype associations in two disease datasets suggests that iCircos has the potential to accelerate translational discoveries in complex disease datasets. We conclude by discussing insights about designing visual analytical systems for translational bioinformatics, and present our future plans for user testing and adding advanced interactivity to the prototype.