Digitisation and 3d reconstruction of 30 year old microscopic sections of human embryo, foetus and orbit

Authors:
Joris E. van Zwieten;Charl P. Botha;Ben Willekens;Sander Schutte;Frits H. Post;Huib J. Simonsz
Affiliations:
Data Visualisation Group, Delft University of Technology;Data Visualisation Group, Delft University of Technology;The Netherlands Ophthalmic Research Institute, Amsterdam;Biomechanical Engineering, Delft University of Technology;Data Visualisation Group, Delft University of Technology;Ophthalmology Department, Erasmus Medical Centre, Rotterdam
Venue:
ICIAR'06 Proceedings of the Third international conference on Image Analysis and Recognition - Volume Part II
Year:
2006

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A global energy function for the alignment of serially acquired slices

IEEE Transactions on Information Technology in Biomedicine

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Abstract

A collection of 2200 microscopic sections was recently recovered at the Netherlands Ophthalmic Research Institute and the Department of Anatomy and Embryology of the Academic Medical Centre in Amsterdam. The sections were created thirty years ago and constitute the largest and most detailed study of human orbital anatomy to date. In order to preserve the collection, it was digitised. This paper documents a practical approach to the automatic reconstruction of a 3-D representation of the original objects from the digitised sections. To illustrate the results of our approach, we show a multi-planar reconstruction and a 3-D direct volume rendering of a reconstructed foetal head.