Improved correspondence for DTI population studies via unbiased atlas building

  • Authors:
  • Casey Goodlett;Brad Davis;Remi Jean;John Gilmore;Guido Gerig

  • Affiliations:
  • Department of Computer Science, University of North Carolina;Department of Computer Science, University of North Carolina;Department of Psychiatry, University of North Carolina;Department of Psychiatry, University of North Carolina;Department of Computer Science, University of North Carolina

  • Venue:
  • MICCAI'06 Proceedings of the 9th international conference on Medical Image Computing and Computer-Assisted Intervention - Volume Part II
  • Year:
  • 2006

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Abstract

We present a method for automatically finding correspondence in Diffusion Tensor Imaging (DTI) from deformable registration to a common atlas. The registration jointly produces an average DTI atlas, which is unbiased with respect to the choice of a template image, along with diffeomorphic correspondence between each image. The registration image match metric uses a feature detector for thin fiber structures of white matter, and interpolation and averaging of diffusion tensors use the Riemannian symmetric space framework. The anatomically significant correspondence provides a basis for comparison of tensor features and fiber tract geometry in clinical studies and for building DTI population atlases.