Objective PET lesion segmentation using a spherical mean shift algorithm

  • Authors:
  • Thomas B. Sebastian;Ravindra M. Manjeshwar;Timothy J. Akhurst;James V. Miller

  • Affiliations:
  • GE Research, Niskayuna, NY;GE Research, Niskayuna, NY;Department of Nuclear Medicine, MSK Cancer Center, New York, NY;GE Research, Niskayuna, NY

  • Venue:
  • MICCAI'06 Proceedings of the 9th international conference on Medical Image Computing and Computer-Assisted Intervention - Volume Part II
  • Year:
  • 2006

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Abstract

PET imagery is a valuable oncology tool for characterizing lesions and assessing lesion response to therapy. These assessments require accurate delineation of the lesion. This is a challenging task for clinicians due to small tumor sizes, blurred boundaries from the large point-spread-function and respiratory motion, inhomogeneous uptake, and nearby high uptake regions. These aspects have led to great variability in lesion assessment amongst clinicians. In this paper, we describe a segmentation algorithm for PET lesions which yields objective segmentations without operator variability. The technique is based on the mean shift algorithm, applied in a spherical coordinate frame to yield a directional assessment of foreground and background and a varying background model. We analyze the algorithm using clinically relevant hybrid digital phantoms and illustrate its effectiveness relative to other techniques.