Construction of correlation networks with explicit time-slices using time-lagged, variable interval standard and partial correlation coefficients

Authors:
Wouter Meuleman;Monique C. M. Welten;Fons J. Verbeek
Affiliations:
Leiden Institute of Advanced Computer Science (LIACS), Leiden University, Leiden, The Netherlands;Leiden Institute of Advanced Computer Science (LIACS), Leiden University, Leiden, The Netherlands;Leiden Institute of Advanced Computer Science (LIACS), Leiden University, Leiden, The Netherlands
Venue:
CompLife'06 Proceedings of the Second international conference on Computational Life Sciences
Year:
2006

Citing 3
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Abstract

The construction of gene regulatory models from microarray time-series data has received much attention. Here we propose a method that extends standard correlation networks to incorporate explicit time-slices. The method is applied to a time-series dataset of a study on gene expression in the developmental phase of zebrafish. Results show that the method is able to distinguish real relations between genes from the data. These relations are explicitly placed in time, allowing for a better understanding of gene regulation. The method and data normalisation procedure have been implemented using the R statistical language and are available from http://zebrafish.liacs.nl/supplements.html.