Overlaps help: improved bounds for group testing with interval queries

  • Authors:
  • Ferdinando Cicalese;Peter Damaschke;Libertad Tansini;Sören Werth

  • Affiliations:
  • AG Genominformatik, Technische Fakultät, Universität Bielefeld, Germany;School of Computer Science and Engineering, Chalmers University, Göteborg, Sweden;School of Computer Science and Engineering, Chalmers University, Göteborg, Sweden;Mathematisches Seminar Bereich 2, University Kiel, Kiel, Germany

  • Venue:
  • COCOON'05 Proceedings of the 11th annual international conference on Computing and Combinatorics
  • Year:
  • 2005

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Abstract

Given a finite ordered set of items and an unknown distinguished subset P of up to p positive elements, identify the items in P by asking the least number of queries of the type “does the subset Q intersect P?”, where Q is a subset of consecutive elements of {1, 2, ..., n}. This problem arises e.g. in computational biology, in a particular method for determining splice sites. We consider time-efficient algorithms where queries are arranged in a fixed number s of stages: in each stage, queries are performed in parallel. In a recent paper we devised query-optimal strategies in the special cases p=1 or s=2, subject to lower-order terms. Exploiting new ideas we are now able to provide a much neater argument that allows doubling the general lower bound for any p≥ 2 and s≥ 3. Moreover, we provide new strategies that match this new bound up to the constant of the main term. The new query scheme shows an effective use of overlapping queries within a stage. Remarkably, this contrasts with the known results for s ≤ 2 where optimal strategies were implemented by disjoint queries.