Mining time-delayed coherent patterns in time series gene expression data

  • Authors:
  • Linjun Yin;Guoren Wang;Keming Mao;Yuhai Zhao

  • Affiliations:
  • Northeastern University, China;Northeastern University, China;Northeastern University, China;Northeastern University, China

  • Venue:
  • ADMA'06 Proceedings of the Second international conference on Advanced Data Mining and Applications
  • Year:
  • 2006

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Abstract

Unlike previous pattern-based biclustering methods that focus on grouping objects on the same subset of dimensions, in this paper, we propose a novel model of coherent cluster for time series gene expression data, namely td-cluster (time-delayed cluster). Under this model, objects can be coherent on different subsets of dimensions if these objects follow a certain time-delayed relationship. Such a cluster can discover the cycle time of gene expression, which is essential in revealing the gene regulatory networks. This work is missed by previous research. A novel algorithm is also presented and implemented to mine all the significant td-clusters. Experimental results from both real and synthetic microarray datasets prove its effectiveness and efficiency.