DNA computing model of the integer linear programming problem based on molecular beacon

  • Authors:

  • Zhi-xiang Yin;Jian-zhong Cui;Jin Yang;Jin Xu

  • Affiliations:

  • ,Department of Mathematics and Physics, Anhui University of Science and Technology, Anhui Huainan, China;Department of Mathematics and Physics, Anhui University of Science and Technology, Anhui Huainan, China;Department of Mathematics and Physics, Anhui University of Science and Technology, Anhui Huainan, China;Department of Mathematics and Physics, Anhui University of Science and Technology, Anhui Huainan, China

  • Venue:
  • ICIC'06 Proceedings of the 2006 international conference on Computational Intelligence and Bioinformatics - Volume Part III
  • Year:
  • 2006

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Abstract

Biological chip technology and DNA computing are new research areas in biology science and information science separately. The essential characteristic of both is the massive parallel of obtaining and managing information. The integer linear programming problem is an important problem in opsearch and it is an NP-complete problem. But up to now, there does not exist any good algorithm yet. A new DNA computing model is provided to solve a integer linear programming problem based on Molecular Beacon chip. In the method, the integer linear programming problem is solved with molecular beacon by fluorescing upon hybridization to their complementary DNA targets. The method has some significant advantages such as simple encoding, excellent sensitivity, high selectivity, low cost, low error, short operating time, reusable surface and simple experimental steps. The result suggest s the potential of Molecular Beacon used as a DNA computer chip.