Gene selection by cooperative competition clustering

  • Authors:
  • Shun Pei;De-Shuang Huang;Kang Li;George W. Irwin

  • Affiliations:
  • ,Intelligent Computing Lab, Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui, China;Intelligent Computing Lab, Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui, China;School of Electrical & Electronic Engineering Queen's University Belfast;School of Electrical & Electronic Engineering Queen's University Belfast

  • Venue:
  • ICIC'06 Proceedings of the 2006 international conference on Computational Intelligence and Bioinformatics - Volume Part III
  • Year:
  • 2006

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Abstract

Clustering analysis of data from DNA microarray hybridization studies is an essential task for identifying biologically relevant groups of genes. Attribute cluster algorithm (ACA) has provided an attractive way to group and select meaningful genes. However, ACA needs much prior knowledge about the genes to set the number of clusters. In practical applications, if the number of clusters is misspecified, the performance of the ACA will deteriorate rapidly. In fact, it is a very demanding to do that because of our little knowledge.We propose the Cooperative Competition Cluster Algorithm (CCCA) in this paper. In the algorithm, we assume that both cooperation and competition exist simultaneously between clusters in the process of clustering. By using this principle of Cooperative Competition, the number of clusters can be found in the process of clustering. Experimental results on a synthetic and gene expression data are demonstrated. The results show that CCCA can choose the number of clusters automatically and get excellent performance with respect to other competing methods.