An introduction to support Vector Machines: and other kernel-based learning methods
An introduction to support Vector Machines: and other kernel-based learning methods
Microarrays for an Integrative Genomics
Microarrays for an Integrative Genomics
Artificial Immune Recognition System (AIRS): An Immune-Inspired Supervised Learning Algorithm
Genetic Programming and Evolvable Machines
CIMCA '05 Proceedings of the International Conference on Computational Intelligence for Modelling, Control and Automation and International Conference on Intelligent Agents, Web Technologies and Internet Commerce Vol-2 (CIMCA-IAWTIC'06) - Volume 02
| Hi-index | 0.00 |
Microarrays allow biologists to better understand the interactions between diverse pathologic states at the gene level. However, the amount of data generated by these tools becomes problematic. New techniques are then needed in order to extract valuable information about gene activity in sensitive processes like tumor cells proliferation and metastasis activity. Recent tools that analyze microarray expression data have exploited correlation-based approach such as clustering analysis. Here we describe a novel GA/ANN based method for assessing the importance of genes for sample classification based on expression data. Several different approaches have been exploited and a com-parison has been given. The developed system has been employed in the classification of ER+/- metastasis recurrence of breast cancer tumours and results were validated using a real life database. Further validation has been carried out using Gene Ontology based tools. Results proved the valuable potentialities and robustness of similar systems.