Data mining: practical machine learning tools and techniques with Java implementations
Data mining: practical machine learning tools and techniques with Java implementations
Prediction of Signal Peptides and Signal Anchors by a Hidden Markov Model
ISMB '98 Proceedings of the 6th International Conference on Intelligent Systems for Molecular Biology
Finding Signal Peptides in Human Protein Sequences Using Recurrent Neural Networks
WABI '02 Proceedings of the Second International Workshop on Algorithms in Bioinformatics
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A challenging problem in data mining is the application of efficient techniques to automatically annotate the vast databases of biological sequence data. This paper describes one such application in this area, to the prediction of the position of signal peptide cleavage points along protein sequences. It is shown that the method, based on Bayesian statistics, is comparable in terms of accuracy to the existing state-of-the-art neural network techniques while providing explanatory information for its predictions.