Normalized Cuts and Image Segmentation
IEEE Transactions on Pattern Analysis and Machine Intelligence
Co-clustering documents and words using bipartite spectral graph partitioning
Proceedings of the seventh ACM SIGKDD international conference on Knowledge discovery and data mining
Biclustering of Expression Data
Proceedings of the Eighth International Conference on Intelligent Systems for Molecular Biology
Biclustering Algorithms for Biological Data Analysis: A Survey
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
Proceedings of the eleventh ACM SIGKDD international conference on Knowledge discovery in data mining
Spectral clustering for multi-type relational data
ICML '06 Proceedings of the 23rd international conference on Machine learning
Dense subgraph computation via stochastic search
Bioinformatics
Learning Spectral Clustering, With Application To Speech Separation
The Journal of Machine Learning Research
A probabilistic framework for relational clustering
Proceedings of the 13th ACM SIGKDD international conference on Knowledge discovery and data mining
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Alteration of gene expression in response to regulatory molecules or mutations could lead to different diseases. MicroRNAs (miRNAs) have been discovered to be involved in regulation of gene expression and can lead to a wide variety of diseases. In a tripartite biological network of human miRNAs, their predicted target genes and the diseases caused by altered expressions of these genes, valuable knowledge about the pathogenicity of miRNAs, involved genes and related disease classes can be revealed by co-clustering miRNAs, target genes and diseases simultaneously. Here we report a spectral co-clustering algorithm for k-partite graph to find clusters with heterogeneous members. We use the method to explore the potential relationships among miRNAs, genes and diseases. The clusters obtained from the algorithm have significantly higher density than random clusters. Results also show that miRNAs in the same family tend to belong to the same cluster. We further validate the results by checking the correlation of enriched gene functions and diseases in the same cluster. Finally miR-17-92 and its paralogs are analyzed as a case study to reveal that genes and diseases co-clustered with the miRNAs are in accordance with current research findings.