Model-based assessment of baroreflex and cardiopulmonary couplings during graded head-up tilt

  • Authors:

  • Alberto Porta;Tito Bassani;Vlasta Bari;Eleonora Tobaldini;Anielle C. M. Takahashi;Aparecida M. Catai;Nicola Montano

  • Affiliations:

  • Department of Technologies for Health, Galeazzi Orthopedic Institute, University of Milan, Milan, Italy;Department of Technologies for Health, Galeazzi Orthopedic Institute, University of Milan, Milan, Italy and Department of Bioengineering, Polytechnic University of Milan, Milan, Italy;Department of Technologies for Health, Galeazzi Orthopedic Institute, University of Milan, Milan, Italy;Department of Clinical Sciences, Internal Medicine II, L. Sacco Hospital, University of Milan, Milan, Italy;Department of Physiotherapy, Federal University of São Carlos, São Carlos, Brazil;Department of Physiotherapy, Federal University of São Carlos, São Carlos, Brazil;Department of Clinical Sciences, Internal Medicine II, L. Sacco Hospital, University of Milan, Milan, Italy

  • Venue:
  • Computers in Biology and Medicine
  • Year:
  • 2012

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Abstract

We propose a multivariate dynamical adjustment (MDA) modeling approach to assess the strength of baroreflex and cardiopulmonary couplings from spontaneous cardiovascular variabilities. Open loop MDA (OLMDA) and closed loop MDA (CLMDA) models were compared. The coupling strength was assessed during progressive sympathetic activation induced by graded head-up tilt. Both OLMDA and CLMDA models suggested that baroreflex coupling progressively increased with tilt table inclination. Only CLMDA model indicated that cardiopulmonary coupling due to the direct link from respiration to heart period gradually decreased with tilt table angles, while that due to the indirect link mediated by systolic arterial pressure progressively increased.