A sparse spatial linear regression model for fMRI data analysis

  • Authors:
  • Vangelis P. Oikonomou;Konstantinos Blekas

  • Affiliations:
  • Department of Computer Science, University of Ioannina, Ioannina, GREECE;Department of Computer Science, University of Ioannina, Ioannina, GREECE

  • Venue:
  • SETN'10 Proceedings of the 6th Hellenic conference on Artificial Intelligence: theories, models and applications
  • Year:
  • 2010

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Abstract

In this study we present an advanced Bayesian framework for the analysis of functional Magnetic Resonance Imaging (fMRI) data that simultaneously employs both spatial and sparse properties The basic building block of our method is the general linear model (GML) that constitute a well-known probabilistic approach for regression By treating regression coefficients as random variables, we can apply an appropriate Gibbs distribution function in order to capture spatial constraints of fMRI time series In the same time, sparse properties are also embedded through a RVM-based sparse prior over coefficients The proposed scheme is described as a maximum a posteriori (MAP) approach, where the known Expectation Maximization (EM) algorithm is applied offering closed form update equations We have demonstrated that our method produces improved performance and enhanced functional activation detection in both simulated data and real applications.