Error-free and best-fit extensions of partially defined Boolean functions
Information and Computation
On Learning Gene Regulatory Networks Under the Boolean Network Model
Machine Learning
Simulation study in Probabilistic Boolean Network models for genetic regulatory networks
International Journal of Data Mining and Bioinformatics
A new multiple regression approach for the construction of genetic regulatory networks
Artificial Intelligence in Medicine
Multiscale Binarization of Gene Expression Data for Reconstructing Boolean Networks
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
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In this paper, we propose a computational method for estimating gene networks by the Boolean network model. The Boolean networks have some practical problems in analyzing DNA microarray gene expression data: One is the choice of threshold value for discretization of gene expression data, since expression data take continuous variables. The other problem is that it is often the case that the optimal gene network is not determined uniquely and it is difficult to choose the optimal one from the candidates by using expression data only. To solve these problems, we use the binding location data produced by Lee et al.[8] together with expression data and illustrate a strategy to decide the optimal threshold and gene network. To show the effectiveness of the proposed method, we analyze Saccharomyces cerevisiae cell cycle gene expression data as a real application.