Recent Methods for RNA Modeling Using Stochastic Context-Free Grammars
CPM '94 Proceedings of the 5th Annual Symposium on Combinatorial Pattern Matching
Approximation of RNA multiple structural alignment
CPM'06 Proceedings of the 17th Annual conference on Combinatorial Pattern Matching
RNA secondary structure prediction via energy density minimization
RECOMB'06 Proceedings of the 10th annual international conference on Research in Computational Molecular Biology
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As one of the earliest problems in computational biology, RNA secondary structure prediction (sometimes referred to as “RNA folding”) problem has attracted attention again, thanking to the recent discoveries of many novel non-coding RNA molecules. The two common approaches to this problem are de novo prediction of RNA secondary structure based on energy minimization and “consensus folding” approach (computing the common secondary structure for a set of unaligned RNA sequences). Consensus folding algorithms work well when the correct seed alignment is part of the input to the problem. However, seed alignment itself is a challenging problem for diverged RNA families. In this paper, we propose a novel framework to predict the common secondary structure for unaligned RNA sequences. By matching putative stacks in RNA sequences, we make use of both primary sequence information and thermodynamic stability for prediction at the same time. We show that our method can predict the correct common RNA secondary structures even when we are only given a limited number of unaligned RNA sequences, and it outperforms current algorithms in sensitivity and accuracy.