Biomimetic in silico devices

Authors:
C. Anthony Hunt;Glen E. P. Ropella;Michael S. Roberts;Li Yan
Affiliations:
Dept. of Biopharmaceutical Sciences, Biosystems Group, University of California, San Francisco, CA;Dept. of Biopharmaceutical Sciences, Biosystems Group, University of California, San Francisco, CA;Department of Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Australia;Joint UCSF/UC Berkeley Bioengineering Graduate Program
Venue:
CMSB'04 Proceedings of the 20 international conference on Computational Methods in Systems Biology
Year:
2004

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Abstract

We introduce biomimetic in silico devices, and means for validation along with methods for testing and refining them. The devices are constructed from adaptable software components designed to map logically to biological components at multiple levels of resolution. In this report we focus on the liver; the goal is to validate components that mimic features of the lobule (the hepatic primary functional unit) and dynamic aspects of liver behavior, structure, and function. An assembly of lobule-mimetic devices represents an in silico liver. We validate against outflow profiles for sucrose administered as a bolus to isolated, perfused rat livers. Acceptable in silico profiles are experimentally indistinguishable from those of the in situ referent. This new technology is intended to provide powerful new tools for challenging our understanding of how biological functional units function in vivo.