Formulating queries for assessing clinical trial eligibility

  • Authors:

  • Deryle Lonsdale;Clint Tustison;Craig Parker;David W. Embley

  • Affiliations:

  • Brigham Young University, Provo, UT;Brigham Young University, Provo, UT;Brigham Young University, Provo, UT;Brigham Young University, Provo, UT

  • Venue:
  • NLDB'06 Proceedings of the 11th international conference on Applications of Natural Language to Information Systems
  • Year:
  • 2006

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Abstract

This paper introduces a system that processes clinical trials using a combination of natural language processing and database techniques. We process web-based clinical trial recruitment pages to extract semantic information reflecting eligibility criteria for potential participants. From this information we then formulate a query that can match criteria against medical data in patient records. The resulting system reflects a tight coupling of web-based information extraction, natural language processing, medical informatic approaches to clinical knowledge representation, and large-scale database technologies. We present an evaluation of the system and future directions for further system development.