A classification-based glioma diffusion model using MRI data

  • Authors:
  • Marianne Morris;Russell Greiner;Jörg Sander;Albert Murtha;Mark Schmidt

  • Affiliations:
  • Department of Computing Science, University of Alberta, Edmonton, AB, Canada;Department of Computing Science, University of Alberta, Edmonton, AB, Canada;Department of Computing Science, University of Alberta, Edmonton, AB, Canada;Department of Radiation Oncology, Cross Cancer Institute, Edmonton, AB, Canada;Department of Computing Science, University of Alberta, Edmonton, AB, Canada

  • Venue:
  • AI'06 Proceedings of the 19th international conference on Advances in Artificial Intelligence: Canadian Society for Computational Studies of Intelligence
  • Year:
  • 2006

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Abstract

Gliomas are diffuse, invasive brain tumors. We propose a 3D classification-based diffusion model, CDM, that predicts how a glioma will grow at a voxel-level, on the basis of features specific to the patient, properties of the tumor, and attributes of that voxel. We use Supervised Learning algorithms to learn this general model, by observing the growth patterns of gliomas from other patients. Our empirical results on clinical data demonstrate that our learned CDM model can, in most cases, predict glioma growth more effectively than two standard models: uniform radial growth across all tissue types, and another that assumes faster diffusion in white matter.