Numerical recipes in C (2nd ed.): the art of scientific computing
Numerical recipes in C (2nd ed.): the art of scientific computing
A formal basis for architectural connection
ACM Transactions on Software Engineering and Methodology (TOSEM)
The Unified Modeling Language user guide
The Unified Modeling Language user guide
Simulating, Analyzing, and Animating Dynamical Systems: A Guide Toi Xppaut for Researchers and Students
Computational Challenges in Cell Simulation: A Software Engineering Approach
IEEE Intelligent Systems
Specifying Distributed Software Architectures
Proceedings of the 5th European Software Engineering Conference
Exposing the Skeleton in the Coordination Closet
COORDINATION '97 Proceedings of the Second International Conference on Coordination Languages and Models
GCF: a general coupling framework
Concurrency and Computation: Practice & Experience - Computational Frameworks
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When modelling complex biological systems it is often desirable to combine a number of distinct sub-models to form a larger composite model. We describe an XML based language that can be used to specify composite models and a lightweight computational framework that executes these models. The language supports specification of structure and implementation details for composite models, along with the interfaces provided by each sub-model. The framework executes each sub-model in its native environment, allowing extensive reuse of existing models. It uses mathematical and computational connectors and translators to unify the models computationally. Unlike other suggested approaches for model integration, our approach does not impose one modeling scheme, composition algorithm or underlying middleware framework. We demonstrate our approach by constructing a composite model describing part of the glucose homeostasis system.