Cluster Analysis for Gene Expression Data: A Survey
IEEE Transactions on Knowledge and Data Engineering
The Journal of Machine Learning Research
Information theoretic measures for clusterings comparison: is a correction for chance necessary?
ICML '09 Proceedings of the 26th Annual International Conference on Machine Learning
Identification and Modeling of Genes with Diurnal Oscillations from Microarray Time Series Data
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
The Journal of Machine Learning Research
Learning Non-Stationary Dynamic Bayesian Networks
The Journal of Machine Learning Research
Automatic annotation of protein functional class from sparse and imbalanced data sets
VDMB'06 Proceedings of the First international conference on Data Mining and Bioinformatics
Learning bayesian networks does not have to be NP-Hard
MFCS'06 Proceedings of the 31st international conference on Mathematical Foundations of Computer Science
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Cyanobacteria are photosynthetic organisms that are credited with both the creation and replenishment of the oxygen-rich atmosphere, and are also responsible for more than half of the primary production on earth. Despite their crucial evolutionary and environmental roles, the study of these organisms has lagged behind other model organisms. This paper presents preliminary results on our ongoing research to unravel the biological interactions occurring within cyanobacteria. We develop an analysis framework that leverages recently developed bioinformatics and machine learning tools, such as genome-wide sequence matching based annotation, gene ontology analysis, cluster analysis and dynamic Bayesian network. Together, these tools allow us to overcome the lack of knowledge of less well-studied organisms, and reveal interesting relationships among their biological processes. Experiments on the Cyanothece bacterium demonstrate the practicability and usefulness of our approach.