Translational bioinformatics: challenges and opportunities for case-based reasoning and decision support

Authors:
Riccardo Bellazzi;Cristiana Larizza;Matteo Gabetta;Giuseppe Milani;Angelo Nuzzo;Valentina Favalli;Eloisa Arbustini
Affiliations:
Dipartimento di Informatica e Sistemistica, Università di Pavia, Pavia, Italy;Dipartimento di Informatica e Sistemistica, Università di Pavia, Pavia, Italy;Dipartimento di Informatica e Sistemistica, Università di Pavia, Pavia, Italy;Dipartimento di Informatica e Sistemistica, Università di Pavia, Pavia, Italy;Dipartimento di Informatica e Sistemistica, Università di Pavia, Pavia, Italy;IRCCS Fondazione Policlinico S. Matteo, Pavia, Italy;IRCCS Fondazione Policlinico S. Matteo, Pavia, Italy
Venue:
ICCBR'10 Proceedings of the 18th international conference on Case-Based Reasoning Research and Development
Year:
2010

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Abstract

Translational bioinformatics is bioinformatics applied to human health. Although, up to now, its main focus has been to support molecular medicine research, translational bioinformatics has now the opportunity to design clinical decision support systems based on the combination of -omics data and internet-based knowledge resources. The paper describes the state-of-art of translational bioinformatics highlighting challenges and opportunities for decision support tools and case-based reasoning. It finally reports the design of a new system for supporting diagnosis in dilated cardiomyopathy. The system is able to combine text mining, literature search and case-based retrieval.